Briones, A; Martos, G; Bedu, M; Choteau, T; Josephs, R D; Wielgosz, R I; Ryadnov, M G (2022) An SI traceable reference material for virus-like particles. iScience, 25 (5). 104294

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Abstract

An SI-traceable reference material for virus-like particles is reported. The material addresses the need for developing reference standards to benchmark virus-like gene delivery systems and help harmonise measurement approaches for characterisation and testing. The material is a major component of synthetic polypeptide virus-like particles, which is produced by the state-of-the-art synthetic and analytical chemistry methods used to generate commercial systems. The purity profile of the material is evaluated to the highest metrological order demonstrating traceability to the SI. The material adds to the emerging toolkit of reference standards for quantitative biology.

Item Type:	Article
Keywords:	Analytical chemistry, Nanotechnology, Bioengineering, Materials science, Biomaterials
Subjects:	Biotechnology > Biopharmaceutical Manufacturing and Characterisation
Divisions:	Chemical & Biological Sciences
Identification number/DOI:	10.1016/j.isci.2022.104294
Last Modified:	13 Jun 2022 10:16
URI:	https://eprintspublications.npl.co.uk/id/eprint/9461