Hacker, L; Ivory, A M; Joseph, J; Grohl, J; Zeqiri, B; Rajagopal, S; Bohndiek, S E (2023) A Stable Phantom Material for Optical and Acoustic Imaging. Journal of Visualized Experiments, 196. e65475

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Abstract

Establishing tissue-mimicking biophotonic phantom materials that provide longterm stability are imperative to enable the comparison of biomedical imaging devices across vendors and institutions, support the development of internationally recognized standards, and assist the clinical translation of novel technologies. Here, a manufacturing process is presented that results in a stable, low-cost, tissuemimicking copolymer-in-oil material for use in photoacoustic, optical, and ultrasound standardization efforts.
The base material consists of mineral oil and a copolymer with defined Chemical Abstract Service (CAS) numbers. The protocol presented here yields a representative material with a speed of sound c(f) = 1,481 ± 0.4 m·s-1 at 5 MHz (corresponds to the speed of sound of water at 20 °C), acoustic attenuation α(f) = 6.1 ± 0.06 dB·cm-1 at 5 MHz, optical absorption μa(λ) = 0.05 ± 0.005 mm-1 at 800 nm, and optical scattering μs'(λ) = 1 ± 0.1 mm-1 at 800 nm. The material allows independent tuning of the acoustic and optical properties by respectively varying the polymer concentration or light scattering (titanium dioxide) and absorbing agents (oil-soluble dye). The fabrication of different phantom designs is displayed and the homogeneity of the resulting test objects is confirmed using photoacoustic imaging. Due to its facile, repeatable fabrication process and durability, as well as its biologically relevant properties, the material recipe has high promise in multimodal acoustic-optical
standardization initiatives.

Item Type:	Article
Subjects:	Acoustics > Ultrasound
Divisions:	Medical, Marine & Nuclear
Identification number/DOI:	10.3791/65475
Last Modified:	25 Feb 2025 10:50
URI:	https://eprintspublications.npl.co.uk/id/eprint/10118