Cant, D J H; Pei, Y; Shchukarev, A; Ramstedt, M; Marques, S S; Segundo, M A; Parot, J; Molska, A; Borgos, S E; Shard, A G; Minelli, C (2023) Cryo-XPS for surface characterisation of nanomedicines. The Journal of Physical Chemistry A, 127 (39). pp. 8220-8227.

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Abstract

Nanoparticles used for medical applications commonly possess coatings or surface functionalities intended to provide specific behaviour in vivo, for example the use of PEG to provide stealth properties. Direct, quantitative measurement of the surface chemistry and composition of such systems in a hydrated environment has thus far not been demonstrated, yet such measurements are of great importance for the development of nanomedicine systems. Here we demonstrate the first use of Cryo-XPS for the measurement of two PEG-functionalised nanomedicines: a polymeric drug delivery system and a lipid nanoparticle mRNA carrier. The observed differences between Cryo-XPS and standard XPS measurements indicate the potential of Cryo-XPS for providing quantitative measurements of such nanoparticle systems in hydrated conditions.

Item Type:	Article
Keywords:	nanoparticles; XPS; Cryo; Cryo-XPS; lipid polymer; LNP, PEG; nanomedicines
Subjects:	Nanoscience > Surface and Nanoanalysis
Divisions:	Chemical & Biological Sciences
Identification number/DOI:	10.1021/acs.jpca.3c03879
Last Modified:	17 Sep 2024 09:23
URI:	https://eprintspublications.npl.co.uk/id/eprint/10019