Report/Guide

Adeogun, M; Bunch, J; Dexter, A; Dondi, C; Murta, T; Nikula, C; Shaw, M; Taylor, A; Partarrieu, I; Romanchikova, M; Smith, N; Thomas, S; Venton, J (2021) Metrology for Digital Pathology. Digital pathology cross-theme project report. NPL Report. AS 102

Brochu, F; Cooke, E; Romanchikova, M; Bunch, J; Dexter, A; Steven, R; Thomas, S; Shaw, M; Pilling, J; Ling, S; Strittmatter, N; Wang, Y; Race, A; Fraser, D; Francis, J; Newman, C; Chavda, V; Wood, C; Lavelle, J (2020) Federation of Imaging Data for Life sciences: current status of metadata collection for high content screening, mass spectrometry imaging and light sheet microscopy of AstraZeneca, GlaxoSmithKline and NPL. NPL Report. MS 24

Cooke, E; Hayes, M; Romanchikova, M; Dexter, A; Steven, R; Thomas, S; Shaw, M; Pilling, J; Ling, S; Strittmatter, N; Ivanov, D; Wang, Y; Race, A; Fraser, D; Francis, J; Newman, C; West, A; Lavelle, J (2020) Acquisition and management of high content screening, light-sheet microscopy and mass spectrometry imaging data at AstraZeneca, GlaxoSmithKline and NPL: a survey report. NPL Report. MS 25

Article

Ling, S; Dexter, A; Race, A M; Sharma, S; Hamm, G; Polanska, U M; Rosetta Consortium Cancer Research UK; Marshall, J F; Takats, Z; Brindle, K; Yunera, M O; Poulogiannis, G; Campbell, A D; Sansom, O J; Goodwin, R J A; Bunch, J; Barry, S T (2025) Use of metabolic imaging to monitor the heterogeneity of tumour response following therapeutic mTORC1/2 pathway inhibition. Disease Models & Mechanisms, 18 (2). DMM050804

Belsey, N A; Tyagi, V; Vorng, J-L; Dexter, A; Tsikritsis, D; Zarmpi, P; Guy, R H (2024) Visualization of topical drug delivery with label-free chemical imaging. Proceedings of the SPIE, 12821. 1282107

Steven, R T; Burton, A; Taylor, A J; Robinson, K N; Dexter, A; Nikula, C; Bunch, J (2024) Evaluation of inlet temperature with three different sprayer designs for desorption electrospray ionization mass spectrometry imaging of tissue analysis. Journal of The American Society for Mass Spectrometry, 35 (2). pp. 224-233.

Belsey, N; Dexter, A; Vorng, J-L; Tsikritsis, D; Nikula, C J; Murta, T; Tiddia, M-V; Zhang, J; Gurdak, E; Trindade, G F; Gilmore, I S; Page, L; Roper, C S; Guy, R H; Bettex, M B (2023) Visualisation of drug distribution in skin using correlative optical spectroscopy and mass spectrometry imaging. Journal of Controlled Release, 364. pp. 79-89.

Gonzalez-Fernandez, A; Dexter, A; Nikula, C; Bunch, J (2023) NECTAR: A new algorithm for characterising and correcting noise in QToF-mass spectrometry imaging data. Journal of The American Society for Mass Spectrometry, 34 (11). pp. 2443-2453.

Voorde, J V; Steven, R T; Najumudeen, A K; Ford, C A; Dexter, A; Gonzalez-Fernandez, A; Nikula, C J; Xiang, Y; Ford, L; Stavrakaki, S M; Gilroy, K; Zeiger, L B; Pennel, K; Hatthakarnkul, P; Elia, E A; Nasif, A; Murta, T; Manoli, E; Mason, S; Gillespie, M; Lannagan, T R M; Vlahov, N; Ridgeway, R A; Nixon, C; Raven, A; Mills, M; Athineos, D; Kanellos, G; Nourse, C; Gay, D M; Hughes, M; Burton, A; Yan, B; Sellers, K; Wu, V; de Ridder, K; Shokry, E; Uribe, A H; Clark, W; Clark, G; Kirschner, K; Theinpont, B; Li, V S W; Maddocks, O D K; Barry, S T; Goodwin, R J A; Kinross, J; Edwards, J; Yuneva, M O; Sumpton, D; Takats, Z; Campbell, A D; Bunch, J; Samson, O J (2023) Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature Metabolism, 5. pp. 1303-1318.

Romanchikova, M; Thomas, S A; Dexter, A; Shaw, M; Partarrieu, I; Smith, N; Venton, J; Adeogun, M; Brettle, D; Turpin, R J (2022) Need for measurement science in digital pathology. Journal of Pathology Informatics, 13. 100157

Dexter, A; Tsikritsis, D; Belsey, N A; Thomas, S A; Venton, J; Bunch, J; Romanchikova, M (2022) Next generation digital pathology: emerging trends and measurement challenges for molecular pathology. Journal of Molecular Pathology, 3 (3). pp. 168-181.

Taylor, A J; Tsikritsis, D; Dexter, A; Burton, A; Bunch, J; Belsey, N A (2022) Classification of tablet formulation by desorption electrospray ionisation mass spectrometry and transmission Raman spectroscopy. Journal of Chemometrics, 36 (6). e3412

de Jesus, J M; Costa, C; Burton, A; Palitsin, V; Webb, R; Taylor, A; Nikula, C; Dexter, A; Kaya, F; Chambers, M; Dartois, V; Goodwin, R J A; Bunch, J; Bailey, M J (2021) Correlative Imaging of Trace Elements and Intact Molecular Species in a Single-Tissue Sample at the 50 μm Scale. Analytical Chemistry, 93 (40). pp. 13450-13458.

Murta, T; Steven, R T; Nikula, C J; Thomas, S A; Zeiger, L B; Dexter, A; Elia, E A; Yan, B; Campbell, A D; Goodwin, R J A; Takáts, Z; Sansom, O J; Bunch, J (2021) Implications of Peak Selection in the Interpretation of Unsupervised Mass Spectrometry Imaging Data Analyses. Analytical Chemistry, 93 (4). pp. 2309-2316. ISSN 0003-2700

Najumudeen, A K; Ceteci, F; Fey, S K; Hamm, G; Steven, R T; Hall, H; Nikula, C J; Dexter, A; Murta, T; Race, A M; Sumpton, D; Vlahov, N; Gay, D M; Knight, J R P; Jackstadt, R; Leach, J D G; Ridgway, R A; Johnson, E R; Nixon, C; Hedley, A; Gilroy, K; Clark, W; Malla, S B; Dunne, P D; Rodriguez-Blanco, G; Critchlow, S E; Mrowinska, A; Malviya, G; Solovyev, D; Brown, G; Lewis, D Y; Mackay, G M; Strathdee, D; Tardito, S; Gottlieb, E; Takats, Z; Barry, S T; Goodwin, R J A; Bunch, J; Bushell, M; Campbell, A D; Sansom, O J (2021) The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nature Genetics, 53 (1). pp. 16-26. ISSN 1061-4036

Race, A M; Rae, A; Vorng, J-L; Havelund, R; Dexter, A; Kumar, N; Steven, R T; Passarelli, M K; Tyler, B J; Bunch, J; Gilmore, I S (2020) Correlative Hyperspectral Imaging Using a Dimensionality-Reduction-Based Image Fusion Method. Analytical Chemistry, 92 (16). pp. 10979-10988. ISSN 0003-2700

Hulme, H; Meikle, L M; Strittmatter, N; van der Hooft, J J J; Swales, J; Bragg, R A; Villar, V H; Ormsby, M J; Barnes, S; Brown, S L; Dexter, A; Kamat, M T; Komen, J C; Walker, D; Milling, S; Osterweil, E K; MacDonald, A S; Schofield, C J; Tardito, S; Bunch, J; Douce, G; Edgar, J M; Edrada-Ebel, R; Goodwin, R J A; Burchmore, R; Wall, D M (2020) Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication. Science Advances, 6 (11). eaax6328 ISSN 2375-2548

Dexter, A; Steven, R T; Patel, A; Dailey, L A; Taylor, A; Ball, D; Klapwijk, J; Forbes, B; Page, C P; Bunch, J (2019) Imaging drugs, metabolites and biomarkers in rodent lung: a DESI MS strategy for the evaluation of drug-induced lipidosis. Analytical and Bioanalytical Chemistry, 411 (30). pp. 8023-8032. ISSN 1618-2642

Patel, A; Hoffman, E; Ball, D; Klapwijk, J; Steven, R T; Dexter, A; Bunch, J; Baker, D; Murnane, D; Hutter, V; Page, C; Dailey, L A; Forbes, B (2019) Comparison of Oral, Intranasal and Aerosol Administration of Amiodarone in Rats as a Model of Pulmonary Phospholipidosis. Pharmaceutics, 11 (7). 345 ISSN 1999-4923

Bunch, J; Steven, R; Taylor, A J; Thomas, S A; Race, A; Dexter, A; Hamm, G; Strittmatter, N; Havelund, R; Soares, R F; Campbell, A D; Sansom, O J; Goodwin, R J; Takats, Z (2018) Abstract 5661: A multi modal mass spectrometry imaging strategy to profile the metabolic hallmarks of colorectal cancer. Cancer Research, 78 (13). p. 5661.

Taylor, A J; Dexter, A; Bunch, J (2018) Exploring ion suppression in mass spectrometry imaging of a hetrogeneous tissue. Analytical Chemistry, 90 (9). pp. 5637-5645.

Swales, J G; Dexter, A; Hamm, G; Nilsson, A; Strittmatter, N; Michopoulos, Fi; Hardy, C; Morentin-Gutierrez, P; Mellor, M; Andren, P E; Clench, M R; Bunch, J; Critchlow, S E; Goodwin, R J A (2018) Quantitation of Endogenous Metabolites in Mouse Tumors Using Mass-Spectrometry Imaging. Analytical Chemistry, 90 (10). pp. 6051-6058. ISSN 0003-2700

Dexter, A; Race, A; Steven, R T; Barnes, J R; Hulme, H; Goodwin, R J A; Styles, I B; Bunch, J (2017) Two-phase and graph-based clustering methods for accurate and efficient segmentation of large mass spectrometry images. Analytical Chemistry, 89 (21). pp. 11293-11300.

Hulme, H E*; Meikle, L M*; Wessel, H*; Strittmatter, N*; Swales, J*; Thomson, C*; Nilsson, A*; Nibbs, R J B*; Milling, S*; Andren, P E*; Mackay, C L*; Dexter, A; Bunch, J; Goodwin, R J A*; Burchmore, R*; Wall, D M* (2017) Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection. Sci. Rep., 7. p. 2786.

Steven, R T; Dexter, A; Bunch, J (2016) Investigating MALDI MSI parameters (Part 1) - a systematic survey of the effects of repetition rates up to 20 kHz in continuous raster mode. Methods, 104. pp. 101-110.

Steven, R T; Dexter, A; Bunch, J (2016) Investigating MALDI MSI parameters (Part 2) - on the use of a mechanically shuttered trigger system for improved laser energy stability. Methods, 104. pp. 111-117.

Race, A M; Palmer, A D*; Dexter, A; Steven, R T; Styles, I B*; Bunch, J (2016) SpectralAnalysis: software for the masses. Anal. Chem., 88 (19). pp. 9451-9458.

Dexter, A; Race, A M; Styles, I B*; Bunch, J (2016) Testing for multivariate normality in mass spectrometry imaging data: a robust statistical approach for clustering evaluation and the generation of synthetic mass spectrometry imaging data sets. Anal. Chem., 88 (22). pp. 10893-10899.