Wang, Y W*; Tomlins, P E; Coombes, A G A*; Rides, M (2010) On the determination of Darcy permeability coefficients for a microporous tissue scaffold. Tissue Eng. C, 16 (2). pp. 281-289.

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Abstract

Structural characterisation of porous tissue scaffolds is challenging due to their complexity. Most investigators report the porosity of the material together with an estimate of the mean pore size and the pore size distribution. The usefulness of these measures is limited, especially in predicting the time dependent perfusion characteristics of a degradable, cell-seeded scaffold. A potential solution to this problem is to measure the permeability of the matrix and determine the Darcy permeability coefficient. In this paper we compare Darcy permeability coefficients determined by monitoring the flow of air and fluids through a porous polycaprolactone scaffold in response to a range of pressure differentials. Such measurements can be made directly using the weight or volume of fluid passing through the scaffold in a given time or by monitoring the change in concentration of a molecular probe such as a small molecule or protein. The latter approach provides an insight into potential molecular interactions with the scaffold material and the influence that has on fluid perfusion. The value of permeability coefficient determination for quality assurance purposes is also discussed

Item Type:	Article
Keywords:	Darcy's law, tissue engineering, permeability, porous, tissue scaffold, characterisation, structure
Last Modified:	02 Feb 2018 13:15
URI:	https://eprintspublications.npl.co.uk/id/eprint/4625