Collins, S M; Koster, U; Robinson, A P; Ivanov, P; Cocolios, T E; Russell, B; Fenwick, A J; Bernerd, C; Stegemann, S; Johnston, K; Gerami, A M; Chrysalidis, K; Mohamud, H; Ramirez, N; Bhaisare, A; Mewburn-Crook, J; Cullen, D M; Pietras, B; Pells, S; Dockx, K; Stucki, N; Regan, P H (2023) Determination of the Terbium-152 half-life from mass-separated samples from CERN-ISOLDE and assessment of the radionuclide purity. Applied Radiation and Isotopes, 202. 111044

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Abstract

Terbium-152 is one of four terbium radioisotopes that together form a potential theranostic toolbox for the personalised treatment of tumours. As 152Tb decays by positron emission it can be utilised for diagnostics by positron emission tomography. For use in radiopharmaceuticals and for activity measurements by activity calibrator a high radionuclide purity of the material and an accurate and precise knowledge of the half-life is required. Mass-separation and radiochemical purification provide a production route of high purity 152Tb. In this work, two mass-separated samples from the CERN-ISOLDE facility have been assayed at the National Physical Laboratory to investigate the radionuclide purity and to perform precision measurements of the half-life. These samples have been used to perform four measurements of the half-life by three independent techniques: high-purity germanium gamma-ray spectrometry, ionisation chamber measurements and liquid scintillation counting. From the four measurement campaigns a half-life of 17.8784(95) h has been determined. The reported half-life shows a significant difference to the currently evaluated half-life (z-score = 3.77), with a relative difference of 2.2%. and an order of magnitude improvement in the precision. This work also shows that under controlled conditions the combination of mass-separation and radiochemical separation can provide high-purity 152Tb.

Item Type:	Article
Keywords:	Tb-152; Half-life; Radioactivity; Ionisation chamber; Liquid scintillation counting; TDCR; Gamma-ray spectrometry; PRISMAP; Nuclear Medicine; Theragnostics
Subjects:	Ionising Radiation > Radioactivity
Divisions:	Medical, Marine & Nuclear
Identification number/DOI:	10.1016/j.apradiso.2023.111044
Last Modified:	14 Feb 2024 14:44
URI:	https://eprintspublications.npl.co.uk/id/eprint/9919