Silvestre Patallo, I; Subiel, A; Carter, R; Flynn, S; Schettino, G; Nisbet, A (2023) Characterization of an inorganic scintillator detector for dosimetry in Image-Guided Small Animal Radiotherapy Platforms. Cancers, 15 (3). 987

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Abstract

Dosimetry for preclinical radiotherapy research requires the standardization of dose validation and quality assurance procedures. Except for dose reference measurements, dosimetric quality control of image-guided small animal irradiation platforms is mostly performed with passive detectors (alanine and gafchromic films). This results in the inconvenient task of lengthy post-processing. In this paper, we carried out a dosimetric characterization of an active detection system based on inorganic scintillators in medium-energy X-rays. We implemented a crosscalibration framework based on international dosimetric protocols to assess the energy dependence of the detector. Additionally, we determined relative output factors for very small fields and compared them to other measurement systems (EBT3 film and CMOS sensor). We demonstrated the suitability of the inorganic scintillation system for the development of phantom-based end-to-end tests for dose verification in newly implemented preclinical radiotherapy irradiation techniques.

Item Type:	Article
Keywords:	radiation detectors; radiation dosimetry; preclinical radiotherapy; X-rays
Subjects:	Ionising Radiation > Dosimetry
Divisions:	Medical, Marine & Nuclear
Identification number/DOI:	10.3390/cancers15030987
Last Modified:	31 May 2023 13:11
URI:	https://eprintspublications.npl.co.uk/id/eprint/9746