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Centrifugal liquid sedimentation methods

Minelli, C; Kestens, V; Babick, F; Lerche, D (2022) Centrifugal liquid sedimentation methods. In: Particle separation techniques. Fundamentals, instruments and selected applications. UNSPECIFIED, pp. 541-577. ISBN 9780323854863

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Centrifugal liquid sedimentation (CLS) is a type of analytical centrifuge used to measure particles and nanoparticles properties, primarily Stokes diameter and buoyant density. It is traditionally used for the characterisation of particle formulations in a broad range of industries, from food to pharmaceuticals. Although well established, the CLS method experiences continuous technical innovation and its areas of application are expanding continuously. We discuss the method in this chapter , its underpinning principle and the main types of instrumentations, as well as some of the main areas of applications with a focus on recent developments. We discuss the measurement by CLS of particle characteristics such as particle size distributions, effective density, particle number concentration, coating thickness and agglomeration profiles. We also provide some practical measurement guidelines examples of analysis of complex particle systems, including non-spherical, agglomerated, highly concentrated, heterogeneous and structurally complex particles.

Item Type: Book Chapter/Section
Subjects: Nanoscience > Surface and Nanoanalysis
Divisions: Chemical & Biological Sciences
Last Modified: 22 May 2023 12:43
URI: http://eprintspublications.npl.co.uk/id/eprint/9735

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