Gillen, R; Erlandsson, K; Denis-Bacelar, A M; Thielemans, K; Hutton, B F; McQaid, S (2021) Towards Accurate Partial Volume Correction – Perturbation for SPECT Resolution Estimation. In: 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, 16-23 October 2021, Piscataway, NJ, USA.

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Abstract

The accuracy of quantitative SPECT imaging is limited by relatively poor spatial resolution - known as the Partial Volume Effect. There is currently no consensus on the optimal Partial Volume Correction (PVC) algorithm in the application of SPECT oncology imaging. However, several promising candidates require information on the reconstructed resolution - usually in the form of the point spread function (PSF). A particular challenge that SPECT poses for PVC is that the resolution is known to vary with position in the field-of-view, as well as activity distribution and reconstruction method. In this work, we assessed the viability of using perturbation to measure case-specific resolution. A small point source was used to measure the resolution in phantoms designed to replicate the issues encountered in oncology imaging. This included anthropomorphic phantoms which had not previously been examined in perturbation applications. Results demonstrate that, provided that a sufficient number of iterations is used for the image reconstruction, perturbation can be used to measure a case-specific PSF and can be used to improve the accuracy of PVC in oncology SPECT imaging.

Item Type:	Conference or Workshop Item (Paper)
Subjects:	Ionising Radiation > Dosimetry
Divisions:	Medical, Marine & Nuclear
Identification number/DOI:	10.1109/NSS/MIC44867.2021.9875672
Last Modified:	19 May 2023 13:57
URI:	https://eprintspublications.npl.co.uk/id/eprint/9734