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Realization and dissemination of activity standards for medically important alpha-emitting radionuclides

Bergeron, D E; Kossert, K; Collins, S M; Fenwick, A J (2022) Realization and dissemination of activity standards for medically important alpha-emitting radionuclides. Applied Radiation and Isotopes, 184. 110161

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Abstract

Interest in targeted cancer therapy with alpha-emitting radionuclides is growing. To evaluate emerging radiotherapeutic agents requires precise activity measurements for consistent dose-response relationships and patient-specific dosimetry. National metrology institutes around the world have reported on the development and comparison of activity standards for medically important alpha emitters. This review describes the relevant methods and models underpinning these standards, the generation of new nuclear decay data, and the impacts on preclinical and clinical activity assays using radionuclide calibrators and γ-ray spectrometry.

Item Type: Article
Keywords: Liquid scintillation counting; Coincidence counting; Gamma-ray spectrometry; Ra-223; Ra-224; Ac-225; Th-227; Decay chain; Activity calibration; HPGe; Dose calibrator
Subjects: Ionising Radiation > Radioactivity
Divisions: Medical, Marine & Nuclear
Identification number/DOI: 10.1016/j.apradiso.2022.110161
Last Modified: 13 Apr 2022 12:54
URI: http://eprintspublications.npl.co.uk/id/eprint/9413

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