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Determination of the 161Tb half-life

Collins, S M; Gilligan, C; Pierson, B; Ramirez, N; Goodwin, M; Pearce, A K; Archambault, B C; Haney, M M; Regan, P H (2022) Determination of the 161Tb half-life. Applied Radiation and Isotopes, 182. 110140

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There is significant interest in the use of terbium radioisotopes for applications in cancer therapy and diagnosis. Of these, 161Tb, as a medium energy beta-emitter, is being investigated as a potential alternative to 177Lu. The relatively high proportion of conversion electron and Auger electron emissions per decay make 161Tb an attractive targeted therapeutic. As a product of nuclear fission, 161Tb is also of importance to nuclear forensics. The standard uncertainty of the current evaluated half-life of 6.89(2) d contributes significantly to the standard uncertainty of any decay corrected activity determination made. Furthermore, the accuracy of this evaluated half-life has been called into question by measurements reported in 2020 at the Institute of Radiation Physics (IRP), Switzerland, who reported a half-life of 6.953(2) d. In the current work, the half-life of the 161Tb ground state decay has been measured at three independent laboratories located in the United Kingdom and the United States of America for a total of six determinations using three independent measurement techniques; gamma-ray spectrometry, ionisation chamber and liquid scintillation counting. The half-life determined for 161Tb of 6.9637(29) d confirms the observed 1 % relative increase observed by IRP, though the reported half-lives in this work and at IRP are significantly different (zeta-score = 3.1).

Item Type: Article
Subjects: Ionising Radiation > Radioactivity
Divisions: Medical, Marine & Nuclear
Identification number/DOI: 10.1016/j.apradiso.2022.110140
Last Modified: 11 Apr 2022 13:58
URI: http://eprintspublications.npl.co.uk/id/eprint/9410

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