Wishart, G; Gupta, P; Nisbet, A; Velliou, E; Schettino, Giuseppe (2021) Novel Anticancer and Treatment Sensitizing Compounds against Pancreatic Cancer. Cancers, 13 (12). 2940

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Abstract

Pancreatic cancer is a disease of unmet clinical needs. Considering the poor prognosis and high treatment resistance of this devastating disease, the search for the development, understanding and characterization of potential treatments and/or treatment sensitizers is of clinical importance. The synergy between natural remedies and state-of-the-art cancer treatments has been poorly considered despite evidence of antioxidant, antimicrobial and antitumor capabilities. Moreover, natural chemical compounds have been the source of many approved drugs. This review collates novel and natural compounds explored for their preclinical anticancer, chemosensitizing and radiosensitizing effects for pancreatic cancer. Here, we highlight a number of natural sources in very early preclinical testing that may hold potential to enhance treatment sensitization, and in turn, reduce treatment resistance and toxicity via lowering treatment dose requirements.

Item Type:	Article
Subjects:	Ionising Radiation > Dosimetry
Divisions:	Medical, Marine & Nuclear
Identification number/DOI:	10.3390/cancers13122940
Last Modified:	23 Mar 2022 14:00
URI:	https://eprintspublications.npl.co.uk/id/eprint/9386