Siekkinen, R; Kirjavainen, A K; Koskensalo, K; Smith, N A S; Fenwick, A J; Saunavaara, V; Tolvanen, T; Iida, H; Saraste, A; Teräs, M; Teuho, J (2021) Assessment of a digital and an analog PET/CT system for accurate myocardial perfusion imaging with a flow phantom. Journal of Nuclear Cardiology, 29. pp. 1964-1972. ISSN 1071-3581

Preview

Text eid9266.pdf - Published Version Available under License Creative Commons Attribution. Download (684kB) | Preview

Abstract

In Myocardial Perfusion Imaging (MPI) with Positron Emission Tomography/ Computed Tomography (PET/CT) systems, accurate quantification is essential. We assessed flow quantification accuracy over various injected activities using a flow phantom.

Methods. The study was performed on the digital 4-ring Discovery MI (DMI-20) and analog Discovery 690 (D690) PET/CT systems, using 325-1257 MBq of [15O]H2O. PET performance and flow quantification accuracy were assessed in terms of count-rates, dead-time factors (DTF), scatter fractions (SF), time-activity curves (TACs), areas-under-the-curves (AUCs) and flow values.

Results. On DMI-20, prompts of 12.8 Mcps, DTF of 2.06 and SF of 46.1% were measured with 1257 MBq of activity. On the D690, prompts of 6.85 Mcps, DTF of 1.57 and SF of 32.5% were measured with 1230 MBq of activity. AUC values were linear over all activities. Mean wash-in flow error was 2 9% for both systems whereas wash-out flow error was 2 5% and 2 6% for DMI-20 and D690. With the highest activity, wash-out flow error was 2 12% and 2 7% for the DMI-20 and D690.

Conclusion. DMI-20 and D690 preserved accurate flow quantification over all injected activities, with maximum error of 2 12%. In the future, flow quantification accuracy over the activities and count-rates evaluated in this study should be assessed.

Item Type:	Article
Subjects:	Ionising Radiation > Radioactivity
Divisions:	Medical, Marine & Nuclear
Identification number/DOI:	10.1007/s12350-021-02631-9
Last Modified:	21 Oct 2022 10:21
URI:	https://eprintspublications.npl.co.uk/id/eprint/9266