Bradley, D A; Sani, S F A; Shafiqah, A S S; Collins, S M; Hugtenburg, R P; Rashid, H A A; Zulkepely, N N; Maah, M J (2018) Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223 Ra. Applied Radiation and Isotopes, 138. pp. 65-72. ISSN 09698043

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Abstract

Using tailor-made sub-mm dimension doped-silica fibres, thermoluminescent dosimetric studies of an α-emitting source of 223RaCl2 (the basis of the Bayer Healthcare product Xofigo®) have been performed. The use of 223RaCl2 in the palliative treatment of bone metastases resulting from late-stage castration-resistant prostate cancer is due to its favourable uptake in metabolically active bone metastases. The treatment benefits from the high linear energy transfer (LET) and associated short path length (< 100 µm) of the α-particles emitted by 223Ra and its decay progeny. In seeking to provide for in vitro dosimetry of the α-particles originating from the 223Ra decay series, the TL yield of various forms of Ge-doped SiO2 fibres, including photonic crystal fibre (PCF) collapsed, PCF uncollapsed, flat and single-mode fibres have been investigated. The irradiations of the fibres were performed at the UK National Physical Laboratory (NPL). Notable are the considerable sensitivity of the dosimeters and an effective atomic number Zeff close to that of bone, the glass fibres offering the additional advantage of being able to be placed directly into liquid. The outcome of present research is expected to inform development of doped fibre radiation dosimeters of versatile utility.

Item Type:	Article
Keywords:	alpha particles, silica fibre, dosimetry, thermoluminescence, 223Ra
Subjects:	Ionising Radiation > Radioactivity
Divisions:	Chemical, Medical & Environmental Science
Identification number/DOI:	10.1016/j.apradiso.2017.04.019
Last Modified:	01 Aug 2018 14:07
URI:	https://eprintspublications.npl.co.uk/id/eprint/8050