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Standards and methodologies for characterizing radiobiological impact of high-Z nanoparticles.

Subiel, A; Ashmore, R; Schettino, G (2016) Standards and methodologies for characterizing radiobiological impact of high-Z nanoparticles. Theranostics, 6 (10). pp. 1651-1671.

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Abstract

In recent years, application of high-Z nanoparticles (NP) in cancer treatment and diagnostic has become of a wide research interest with promising translational potentials. In spite of numerous publications related to the development and application of nanoparticles for use with ionizing radiation, the literature is lacking of coherent and systematic experimental approaches to fully evaluate the radiobiological effectiveness of NP, validate mechanistic models and allow direct comparison of the studies undertaken by various research groups. The lack of standards and established methodology is commonly recognised as a major obstacle for the transition into clinical practice of innovative research ideas. This review provides a comprehensive overview of radiobiological techniques and quantification methods so far used in in vitro studies on high-Z nanoparticles and aims to provide recommendations for future standardization for NP-mediated radiation research.

Item Type: Article
Keywords: nanoparticles, Radiobiology
Subjects: Ionising Radiation
Ionising Radiation > Dosimetry
Identification number/DOI: 10.7150/thno.15019
Last Modified: 02 Feb 2018 13:13
URI: http://eprintspublications.npl.co.uk/id/eprint/7172

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