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Future development of biologically relevant dosimetry.

Palmans, H; Rabus, H*; Belchior, A L*; Bug, M U*; Galer, S; Giesen, U*; Gonon, G*; Gruel, G*; Hilgers, G*; Moro, D*; Nettelbeck, H*; Pinto, M*; Pola, A*; Pszona, S*; Schettino, G; Sharpe, P H G; Teles, P*; Villagrasa, C*; Wilkens, J J* (2015) Future development of biologically relevant dosimetry. Brit. J. Radiol., 88 (1045). 20140392

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Proton and ion beams are radiotherapy modalities of increasing importance and interest. Because of the different biological dose response of these radiations as compared to high-energy photon beams, the current approach of treatment prescription is based on the product of the absorbed dose to water and a biological weighting factor, but this is found to be insufficient for providing a generic method to quantify the biological outcome of radiation. It is therefore suggested to define new dosimetric quantities which allow a transparent separation of the physical processes from the biological ones. Given the complexity of the initiation and occurrence of biological processes on various time and length scales and given that neither microdosimetry nor nanodosimetry on its own can fully describe the biological effects as function of the distribution of energy deposition or ionisation a multi-scale approach is needed to lay the foundation for those new physical quantities relating track structure to relative biological effectiveness in proton and ion beam therapy. This paper reviews the state of the art of microdosimetry, nanodosimetry, track structure simulations, quantification of reactive species, reference radiobiological data, cross section data and multi-scale models of biological response in the context of realizing the new quantities. It will also introduce the European metrology project, BioQuaRT which aims at investigating the feasibility of establishing a multi-scale model as the basis of the new quantities.

Item Type: Article
Keywords: radiotherapy, radiation, biologically relevant quantities, multiscale model
Subjects: Ionising Radiation
Ionising Radiation > Dosimetry
Identification number/DOI: 10.1259/brr.20140392
Last Modified: 02 Feb 2018 13:13
URI: http://eprintspublications.npl.co.uk/id/eprint/6596

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