Minelli, C; Liew, J X*; Muthu, M*; Andresen, H* (2013) Coiled coil peptide-functionalized surfaces for reversible molecular binding. Soft Matter, 9 (20). pp. 5119-5124.
Full text not available from this repository.Abstract
We have studied the conformational and self assembly properties of de novo peptides derived from the structure of the yeast transcriptional activator GCN4 in solution and on surfacesand showed how the pH and the polarity of the solvent control peptide conformation. The peptides self-assembled in a coiled coil structure at acidic pH whereas they disassembled at alkaline pH values. Solvent polarity infuenced the peptide ability of forming alpha-helixes. We have used these properties to control the peptide packing density on gold surfaces, and demonstrated with functionalised gold nanoparticles that such peptide-engineered surfaces can be used for reversible molecular binding.
Item Type: | Article |
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Keywords: | Coiled-coils, QCM-D, SPR, molecular binding |
Subjects: | Nanoscience Nanoscience > Surface and Nanoanalysis |
Identification number/DOI: | 10.1039/c3sm50379h |
Last Modified: | 02 Feb 2018 13:14 |
URI: | http://eprintspublications.npl.co.uk/id/eprint/5832 |
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