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Abstract

Precise surface nanopatterning is a promising route for predictable control of cellular behaviour on biomedical materials. There is currently a gap taking such precision engineered surfaces from the laboratory to clinically relevant implant materials such as titanium (Ti). In this work anodisation of Ti surfaces was performed in combination with block copolymer templates to create self-assembled and tuneable nanopatterns. SIMS and XPS analyses showed that the composition of the anodised structures was mainly titania with small amounts of nitrogen left from the block copolymer. It was further demonstrated that these nanopatterns can be generated on more complex shaped Ti surfaces such as microbeads. Human mesenchymal stem cells were cultured in vitro on Ti microbead surfaces, with and without nanopatterns, to study the effect of nanotopography on Ti surfaces. The results presented in this work demonstrate a novel method of producing well defined and tuneable surface nanopatterns for the creation of sophisticated nanotopography on Ti implant surfaces to direct cells fate for intended applications.

Item Type:	Article
Subjects:	Nanoscience Nanoscience > Surface and Nanoanalysis
Identification number/DOI:	10.1021/am301987e
Last Modified:	02 Feb 2018 13:14
URI:	http://eprintspublications.npl.co.uk/id/eprint/5678

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