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Ambient mass spectrometry: advances and applications in forensics.

Green, F M; Salter, T L; Stokes, P*; Gilmore, I S; O'Connor, G* (2010) Ambient mass spectrometry: advances and applications in forensics. Surf. Interface Anal., 42 (5). pp. 347-357.

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Ambient surface mass spectrometry is a powerful and rapidly growing new field that provides high sensitivity mass spectrometry direct from surfaces at ambient pressure. There is now a rich evidence base in the published literature of the success of these methods for forensic analysis including: detection of explosives at ng levels; chemical composition of pharmaceutical tablets, drug detection from biological liquids such as urine and plasma; breath analysis of metabolites; imaging analysis for document verification and fingerprint identification. Recent developments in miniaturised (shoe box sized) mass spectrometers have enabled these developments to be translated to portable on-scene detection and first responder usage. In this review, we illustrate and compare the effectiveness of the most popular and promising techniques of Desorption Electrospray Ionisation (DESI), Direct Analysis in Real Time (DART), Plasma Assisted Desorption Ionisation (PADI) and Extractive Electrospray Surface Ionisation (EESI).

Forensic analysis by its very definition must stand up to scrutiny in a court of law. It is therefore essential that measurements are repeatable, valid and fit for purpose. The establishment of a measurement infrastructure is therefore essential to ensure that the methods used may be accredited and conform to relevant quality systems and procedures

Item Type: Article
Keywords: DESI, ambient mass spectrometry, direct analysis, forensics
Subjects: Nanoscience
Nanoscience > Surface and Nanoanalysis
Last Modified: 02 Feb 2018 13:15
URI: http://eprintspublications.npl.co.uk/id/eprint/4641

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