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Higher-order protein structure measurements for biopharmaceutical quality control.

Ravi, J; LePevelen, D*; Tranter, G*; Knight, A (2007) Higher-order protein structure measurements for biopharmaceutical quality control. NPL Report. AS 9

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Abstract

This report reviews the available techniques for measuring the higher-order structure of proteins, and assesses their suitability for quality control in the biopharmaceutical industry. FTIR is found to be the technique which best compliments CD, currently the dominant technique. We explore measurement issues of FTIR and make best practice recommendations. We also advide that FTIR should be used in combination with CD.

Item Type: Report/Guide (NPL Report)
NPL Report No.: AS 9
Keywords: circular dichroism, FTIR, protein structure, biopharmaceutical
Subjects: Biotechnology
Biotechnology > Biopharmaceutical Manufacturing and Characterisation
Last Modified: 02 Feb 2018 13:15
URI: http://eprintspublications.npl.co.uk/id/eprint/3942

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