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Characterisation and quantitation of post-translationally modified proteins.

Thobhani, S; Bailey, M; Yuen, C-T*; Jones, C* (2007) Characterisation and quantitation of post-translationally modified proteins. NPL Report. AS 6

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Abstract

This report describes work carried out under the Measurements for Biotechnology (MfB) Programme 2004-2007, for addressing comparability issues in glycan analysis when monitoring protein glycosylation.
An inter-laboratory study was undertaken within the UK to assess the comparability of glycan analysis across multiple platforms. The study consisted of a questionnaire and a laboratory based study, in which participants analysed a set of four N-glycans using their routine glycan mapping methodology. Results from the study are to be used to help harmonise the field of glycan analysis and to support writing of pharmacopoeial monographs.

Item Type: Report/Guide (NPL Report)
NPL Report No.: AS 6
Keywords: post-translations modifications, glycosylation, glycan analysis, interlaboratory study, MfB
Subjects: Biotechnology
Biotechnology > Biopharmaceutical Manufacturing and Characterisation
Last Modified: 02 Feb 2018 13:15
URI: http://eprintspublications.npl.co.uk/id/eprint/3939

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