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A review of UK requirements for a measurement infrastructure for radionuclides used in Positron Emission Tomography.

Judge, S M (2004) A review of UK requirements for a measurement infrastructure for radionuclides used in Positron Emission Tomography. NPL Report. DQL-RN 006

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Abstract

Positron Emission Tomography (PET) is a medical imaging technique with many clinical and research applications. The number of PET Centres is set to expand in the UK over the next few years. As with other more established radiopharmaceuticals, the activities of any positron-labelled compounds administered to patients must be assayed to ensure the radiation dose the patient receives is as low as reasonably practicable, compatible with obtaining a good quality image. The National Physical Laboratory (NPL) already provides a UK measurement infrastructure enabling hospitals to achieve traceability to primary standards for ß/ -emitting radionuclides. Positron-emitting radionuclides, however, present additional measurement problems arising from geometric effects and the short half-lives of many of these radionuclides.
This review summarises the technical, regulatory and practical issues concerned with setting up a new infrastructure to ensure that measurements of PET radionuclides are accurate, consistent and traceable to national standards. The report includes feedback from visits to the user community. It concludes by recommending how the infrastructure should be established initially, using the existing NPL sample calibration service combined with a mobile service based on an NPL secondary standard ionisation chamber.

Item Type: Report/Guide (NPL Report)
NPL Report No.: DQL-RN 006
Subjects: Ionising Radiation
Ionising Radiation > Radioactivity
Last Modified: 02 Feb 2018 13:16
URI: http://eprintspublications.npl.co.uk/id/eprint/3236

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