Article

Hoose, A; Garcia-Ruiz, J; Blake, C; Lally, C C M; Briones, A; Hoogenboom, B W; Lorenz, C D; Ryadnov, M G (2025) Multi-modal membrane poration by thanatin. Langmuir, 41 (6). pp. 3757-3767.

Ryadnov, M G (2024) Gene delivery: persistent challenges call for a reference measure. Cell & Gene Therapy Insights, 10 (9). pp. 1313-1316.

Noble, J E; Hsiao, Y-W; Kepiro, I E; de Santis, E; Hoose, A; Augagneur, C; Lamarre, B; Briones, A; Hammond, K; Bray, D J; Crain, J; Ryadnov, M G (2024) A non-linear peptide topology for synthetic virions. ACS Nano, 18 (43). pp. 29956-29967.

Campbell, J J; Almond, N; Bae, Y K; Bhuller, R; Briones, A; Cho, S J; Cleveland, M H; Cleveland IV, T E; Galaway, F; He, H-J; Herbrand, U; Huggett, J F; Kempster, S; Kepiro, I E; Khan, A S; Kwee, E; Li, W; Lin-Gibson, S; Luckau, L; Minelli, C; Ryadnov, M G; Searing, I; Wang, L; Whale, A S; Baybrook, J H (2024) Standards and Metrology for Viral Vectors as Molecular Tools : Outcomes from a CCQM workshop. Biologics, 4 (2). pp. 187-201.

de Santis, E; Faruqui, N; Russell, C T; Noble, J; Kepiro, I; Hammomd, K; Tsalenchuk, M; Ryadnov, E M; Wolna, M; Frogley, M D; Price, C J; Barbaric, I; Cinque, G; Ryadnov, M G (2024) Hyperspectral mapping of human primary and stem cells at cell-matrix interfaces. ACS Applied Materials & Interfaces, 16 (2). pp. 2154-2165.

Noble, J E; Vila-Gomez, P; Rey, S; Dondi, C; Briones, A; Aggarwal, P; Hoose, A; Baran, M; Ryadnov, M G (2023) Folding-mediated DNA delivery by α-helical amphipathic peptides. ACS Biomaterials Science & Engineering, 9 (5). pp. 2584-2595.

Ishak, M I; Eales, M; Damiati, L; Liu, X; Jenkins, J; Dalby, M J; Nobbs, A H; Ryadnov, M G; Su, B (2023) Enhanced and Stem-Cell-Compatible Effects of Nature-Inspired Antimicrobial Nanotopography and Antimicrobial Peptides to Combat Implant-Associated Infection. ACS Applied Nano Materials, 6 (4). pp. 2549-2559.

Zhang, Y; Kepiro, I; Ryadnov, M G; Pagliara, S (2023) Single cell killing kinetics differentiate phenotypic bacterial responses to different antibacterial classes. Microbiology Spectrum, 11 (1). e03667-22

Hoose, A; Vellacott, R; Storch, M; Freemont, P S; Ryadnov, M G (2023) DNA synthesis technologies to close the gene writing gap. Nature Reviews Chemistry, 7. pp. 144-161.

Garcia-Ruiz, J; Ryadnov, M G (2022) DANAMIC: Data Analyzer of Minimum Inhibitory Concentrations as per reference standards for antimicrobial testing. Star Protocols, 3 (4). 101782

Nahas, K A; Fletcher, M; Hammond, K; Nehls, C; Cama, J; Ryadnov, M G; Keyser, U F (2022) Measuring thousands of single vesicle leakage events reveals the mode of action of antimicrobial peptides. Analytical Chemistry, 94 (27). pp. 9530-9539.

Hammond, K; Moffat, J; Mulcahy, C; Hoogenboom, B W; Ryadnov, M G (2022) In situ nanoscale imaging reveals self-concentrating nanomolar antimicrobial pores. Nanoscale, 14 (24). pp. 8586-8593.

Briones, A; Martos, G; Bedu, M; Choteau, T; Josephs, R D; Wielgosz, R I; Ryadnov, M G (2022) An SI traceable reference material for virus-like particles. iScience, 25 (5). 104294

Cama, J; Al Nahas, K; Fletcher, M; Hammond, K; Ryadnov, M G; Keyser, U F; Pagliara, S (2022) An ultrasensitive microfluidic approach reveals correlations between the physico-chemical and biological activity of experimental peptide antibiotics. Scientific Reports, 12 (1). 4005

Hornemann, A; Eichert, D M; Hoehl, A; Tiersch, B; Ulm, G; Ryadnov, M G; Beckhoff, B (2022) Investigating Membrane-Mediated Antimicrobial Peptide Interactions with Synchrotron Radiation Far-Infrared Spectroscopy. ChemPhysChem, 23 (4). e202100815

Benn, G; Mikheyera, I V; Inns, P G; Forster, J C; Ojkic, N; Bortolini, C; Ryadnov, M G; Kleanthous, C; Silhavy, T J; Hoogerboom, B W (2021) Phase separation in the outer membrane of Escherichia coli. PNAS, 118 (44). e2112237118

Hammond, K; Cipcigan, F; Al Nahas, K; Losasso, V; Lewis, H; Cama, J; Martelli, F; Simcock, P W; Fletcher, M; Ravi, J; Stansfeld, P J; Pagliara, S; Hoogenboom, B W; Keyser, U F; Sansom, M S P; Crain, J; Ryadnov, M G (2021) Switching Cytolytic Nanopores into Antimicrobial Fractal Ruptures by a Single Side Chain Mutation. ACS Nano, 15 (6). pp. 9679-9689.

Simcock, P W; Bublitz, M; Cipcigan, F; Ryadnov, M G; Crain, J; Stansfeld, P J; Sansom, M S P (2021) Membrane Binding of Antimicrobial Peptides Is Modulated by Lipid Charge Modification. Journal of Chemical Theory and Computation, 17 (2). pp. 1218-1228. ISSN 1549-9618

Hammond, K; Ryadnov, M G; Hoogenboom, B W (2021) Atomic force microscopy to elucidate how peptides disrupt membranes. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1863 (1). 183447 ISSN 00052736

Hammond, K; Lewis, H; Halliwell, S; Desriac, F; Nardone, B; Ravi, J; Hoogenboom, B W; Upton, M; Derrick, J P; Ryadnov, M G (2020) Flowering Poration—A Synergistic Multi-Mode Antibacterial Mechanism by a Bacteriocin Fold. iScience, 23 (8). 101423 ISSN 25890042

Piarali, S; Marlinghaus, L; Viebahn, R; Lewis, H; Ryadnov, M G; Groll, J; Salber, J; Roy, I (2020) Activated Polyhydroxyalkanoate Meshes Prevent Bacterial Adhesion and Biofilm Development in Regenerative Medicine Applications. Frontiers in Bioengineering and Biotechnology, 8. 442 ISSN 2296-4185

Robinson, J; Berselli, G B; Ryadnov, M G; Keyes, T E (2020) Annexin V Drives Stabilization of Damaged Asymmetric Phospholipid Bilayers. Langmuir, 36 (19). pp. 5454-5465. ISSN 0743-7463

Kepiro, I E; Nardone, B; Page, A; Ryadnov, M G (2020) Revealing Sources of Variation for Reproducible Imaging of Protein Assemblies by Electron Microscopy. Micromachines, 11 (3). 251 ISSN 2072-666X

Simcock, P W; Sansom, M S; Stansfeld, P J; Bublitz, M; Crain, J; Ryadnov, M G; Cipcigan, F (2020) Cationic Antimicrobial Peptides have Reduced Binding to MprF-Modified Membranes. Biophysical Journal, 118 (3). 237a ISSN 00063495

Kepiro, I E; Marzuoli, I; Hammond, K; Ba, X L; Lewis, H; Shaw, M; Gunnoo, S B; de Santis, E; Łapińska, U; Pagliara, S; Holmes, M A; Lorenz, C D; Hoogenboom, B W; Fraternali, F; Ryadnov, M G (2020) Engineering Chirally Blind Protein Pseudocapsids into Antibacterial Persisters. ACS Nano, 14 (2). pp. 1609-1622. ISSN 1936-0851

Faruqui, N; Kummrow, A; Fu, B Q; Divieto, C; Rojas, F; Kisulu, F; Cavalcante, J J V; Wang, J; Campbell, J; Martins, J L; Choi, J H; Sassi, M P; Zucco, M; Vonsky, M; Vessillier, S; Zou, S; Fujii, S I; Ryadnov, M G (2020) Cellular Metrology: Scoping for a Value Proposition in Extra- and Intracellular Measurements. Frontiers in Bioengineering and Biotechnology, 7. 456 ISSN 2296-4185

Benn, G; Pyne, A L B; Ryadnov, M G; Hoogenboom, B W (2019) Imaging live bacteria at the nanoscale: comparison of immobilisation strategies. The Analyst, 144 (23). pp. 6944-6952. ISSN 0003-2654

Chung, L C; Birch, D J S; Vyshemirsky, V; Ryadnov, M G; Rolinski, O J (2019) Tracking Insulin Glycation in Real Time by Time-Resolved Emission Spectroscopy. The Journal of Physical Chemistry B, 123 (37). pp. 7812-7817. ISSN 1520-6106

Hammond, K; Lewis, H; Faruqui, N; Russell, C; Hoogenboom, B W; Ryadnov, M G (2019) Helminth Defense Molecules as Design Templates for Membrane Active Antibiotics. ACS Infectious Diseases, 5 (8). pp. 1471-1479. ISSN 2373-8227

Whitehouse, W L; Noble, J E; Ryadnov, M G; Howorka, S (2019) Cholesterol Anchors Enable Efficient Binding and Intracellular Uptake of DNA Nanostructures. Bioconjugate Chemistry, 30 (7). pp. 1836-1844. ISSN 1043-1802

Chung, L H C; Birch, D J S; Vyshemirsky, V; Bella, A; Ryadnov, M G; Rolinski, O J (2019) Protein fibrillogenesis model tracked by its intrinsic time-resolved emission spectra. Methods and Applications in Fluorescence, 7 (3). 035003 ISSN 2050-6120

Pfeil, M P; Pyne, A L B; Losasso, V; Ravi, J; Lamarre, B; Faruqui, N; Alkassem, H; Hammond, K; Judge, P J; Winn, M; Martyna, G J; Crain, J; Watts, A; Hoogenboom, B; Ryadnov, M G (2018) Author Correction: Tuneable poration: host defense peptides as sequence probes for antimicrobial mechanisms (vol 8, 14926, 2018). Scientific Reports, 8. 17266 ISSN 2045-2322

Pfeil, M P; Pyne, A L B; Losasso, V; Ravi, J; Lamarre, B; Faruqui, N; Alkassem, H; Hammond, K; Judge, P J; Winn, M; Martyna, G J; Crain, J; Watts, A; Hoogenboom, B W; Ryadnov, M G (2018) Tuneable poration: host defense peptides as sequence probes for antimicrobial mechanisms. Scientific Reports, 8 (1). 14926 ISSN 2045-2322

Cipcigan, F; Carrieri, A P; Pyzer-Knapp, E O; Krishna, R; Hsiao, Y-W; Winn, M; Ryadnov, M G; Edge, C; Martyna, G; Crain, J (2018) Accelerating molecular discovery through data and physical sciences: Applications to peptide-membrane interactions. The Journal of Chemical Physics, 148 (24). 241744 ISSN 0021-9606

Burns, J R; Lamarre, B; Pyne, A L B; Noble, J E; Ryadnov, M G (2018) DNA origami inside-out viruses. ACS Synthetic Biology, 7 (3). pp. 767-773. ISSN 2161-5063

de Santis, E; Alkassem, H; Lamarre, B; Faruqui, N; Bella, A; Noble, J E; Micale, N; Ray, S; Burns, J R; Yon, A R; Hoogenboom, B W; Ryadnov, M G (2017) Antimicrobial peptide capsids of de novo design. Nature Communications, 8. 2263

Chung, L H C; Birch, D J S; Vyshemirsky, V; Ryadnov, M G; Rolinski, O J (2017) Insulin aggregation tracked by its intrinsic TRES. Applied Physics Letters, 111 (26). 263701

Shaw, M; Bella, A; Ryadnov, M G (2017) CREIM: coffee ring effect imaging model for monitoring protein self-assembly in situ. Journal of Physical Chemistry Letters, 8 (19). pp. 4846-4851.

Marzuoli, I; Lorenz, M; Ryadnov, M G; Fraternali, F (2017) A computational approach to self-assembly of new antimicrobial peptides. European Biophysics Journal with Biophysics Letters, 46 (Supp 1). S223.

Hayouka, Z*; Bella, A; Stern, T*; Ray, S*; Jiang, H B*; Grovenor, C R M*; Ryadnov, M G (2017) Binary encoding of random peptide sequences for selective and differential antimicrobial mechanisms. Angew. Chem., Int. Ed., 56 (28). pp. 8099-8103.

Pyne, A; Pfeil, M P; Bennett, I*; Ravi, J; Iavicoli, P*; Lamarre, B; Roethke, A*; Ray, S; Jiang, H B*; Bella, A; Reisinger, B*; Yin, D; Little, B*; Munoz-Garcia, J C*; Cerasoli, E; Judge, P J*; Faruqui, N; Calzolai, L*; Henrion, A*; Martyna, G J*; Grovenor, C R M*; Crain, J; Hoogenboom, B W*; Watts, A*; Ryadnov, M G (2017) Engineering monolayer poration for rapid exfoliation of microbial membranes. Chem. Sci., 8 (2). pp. 1105-1115.

Bella, A; Ray, S*; Ryadnov, M G (2017) Linear and orthogonal peptide templating of silicified protein fibres. Organic Biomol. Chem., 15 (25). pp. 5380-5385.

Iavicoli, P*; Rossi, F*; Lamarre, B; Bella, A; Ryadnov, M G; Calzolai, L* (2017) Modulating charge-dependent and folding-mediated antimicrobial interactions at peptide-lipid interfaces. Eur. Biophys. J. with Biophys. Lett., 46 (4). pp. 375-382.

Valsesia, A*; Iavicoli, P*; Lewis, H; Desmet, C*; Mehn, D*; Calzolai, L*; Colpo, P*; Rossi, F*; Ryadnov, M G (2017) Nano-mechanical in-process monitoring of antimicrobial poration in model phospholipid bilayers. RSC Adv., 7 (31). pp. 19081-19084.

Guyader, C P E; Lamarre, B; de Santis, E; Noble, J E; Slater, N K*; Ryadnov, M G (2016) Autonomously folded alpha-helical lockers promote RNAi. Sci. Rep., 6. p. 35012.

Noble, J E; de Santis, E; Ravi, J; Lamarre, B; Castelletto, V*; Mantell, J*; Ray, S*; Ryadnov, M G (2016) A De Novo virus-like topology for synthetic virions. J. Am. Chem. Soc., 138 (37). pp. 12202-12210.

Zajiczek, L; Shaw, M; Faruqui, N; Bella, A; Pawar, V M*; Srinivasan, M A*; Ryadnov, M G (2016) Nano-mechanical single-cell sensing of cell-matrix contacts. Nanoscale, 8 (42). pp. 18105-18112.

Castelletto, V; de Santis, E; Alkassem, H; Lamarre, B; Noble, J E; Ray, S; Bella, A; Burns, J R; Hoogenboom, B W*; Ryadnov, M G (2016) Structurally plastic peptide capsules for synthetic antimicrobial viruses. Chem. Sci., 7 (3). pp. 1707-1711.

Jepson, A K*; Schwarz-Linek, J*; Ryan, L*; Ryadnov, M G; Poon, W C K* (2016) What is the 'minimum inhibitory concentration' (MIC) of pexiganan acting on escherichia coli? - a cautionary case study. Biophysics of Infection, 915. pp. 33-48.

Lavicoli, P*; Urban, P*; Bella, A; Ryadnov, M G; Rossi, F*; Calzolai, L* (2015) Application of asymmetric flow field-flow fractionation hyphenations for liposome-antimicrobial peptide interaction. J. Chromatography A, 1422. pp. 260-269.

de Santis, E; Castelletto, V; Ryadnov, M G (2015) Interfacial zippering-up of coiled-coil protein filaments. Phys. Chem. Chem. Phys., 17 (46). pp. 31055-31060.

de Santis, E; Ryadnov, M G (2015) Peptide self-assembly for nanomaterials: the old new kid on the block. Chem. Soc. Rev., 44 (22). pp. 8288-8300.

Munye, M M*; Ravi, J; Tagalakis, A D*; McCarthy, D*; Ryadnov, M G; Hart, S L* (2015) Role of liposome and peptide in the synergistic enhancement of transfection with a lipopolyplex vector. Sci. Rep., 5. p. 9292.

Ravi, J; Bella, A; Correia, A J V; Lamarre, B; Ryadnov, M G (2015) Supramolecular amphipathicity for probing antimicrobial propensity of host defence peptides. Phys. Chem. Chem. Phys., 17 (24). pp. 15608-15614.

Diu, T*; Faruqui, N; Sjostrom, T*; Lamarre, B; Jenkinson, H F*; Su, B*; Ryadnov, M G (2014) Cicada-inspired cell-instructive nanopatterned arrays. Sci. Rep., 4. p. 7122.

Faruqui, N; Bella, A; Ravi, J; Ray, S; Lamarre, B; Ryadnov, M G (2014) Differentially instructive extracellular protein micro-nets. J. Am. Chem. Soc., 136 (22). pp. 7889-7898.

de Santis, E; Faruqui, N; Noble, J E; Ryadnov, M G (2014) Exploitable length correlations in peptide nanofibres. Nanoscale, 6 (19). pp. 11425-11430.

de Santis, E; Faruqui, N; Noble, J; Ryadnov, M G (2014) Exploiting the relationship between sequence, self-assembly and function for novel peptide scaffolds. J. Pept. Sci., 20. S36.

Bella, A; Shaw, M J; Ray, S; Ryadnov, M G (2014) Filming protein fibrillogenesis in real time. Sci. Rep., 4. p. 7529.

Rakowska, P D; Lamarre, B; Ryadnov, M G (2014) Probing label-free intracellular quantification of free peptide by MALDI-ToF mass spectrometry. Methods, 68 (2). pp. 331-337.

Faruqui, N; Bella, A; Ravi, J; Ray, S; Lamarre, B; Ryadnov, M G (2014) Self-assembled instructive extracellular matrices. Tissue Eng. Part A, 20. S111.

Jiang, H*; Favaro, E*; Goulbourne, C N*; Rakowska, P D; Hughes, G M*; Ryadnov, M G; Fong, L G*; Young, S G*; Ferguson, D J P*; Harris, A L*; Grovenor, C R M* (2014) Stable isotope imaging of biological samples with high resolution secondary ion mass spectrometry and complementary techniques. Methods, 68 (2). pp. 317-324.

Ryadnov, M G (2014) Where is the drug gone? Measuring intracellular delivery and localization introduction. Methods, 68 (2). pp. 281-282.

Ryan, L; Lamarre, B; Diu, T*; Ravi, J; Judge, P J*; Temple, A*; Carr, M*; Cerasoli, E; Su, B*; Jenkinson, H F*; Martyne, G*; Crain, J; Watts, A*; Ryadnov, M G (2013) Anti-antimicrobial peptides folding-mediated host defense antagonists. J. Biol. Chem., 288 (28). pp. 20162-20172.

Rakowska, P D; Jiang, H B*; Ray, S; Pyne, A; Lamarre, B; Carr, M*; Judge, P J*; Ravi, J; Gerling, U I M*; Koksch, B*; Martyna, G J*; Hoogenboom, B W*; Watts, A*; Crain, J; Grovenor, C R M*; Ryadnov, M G (2013) Nanoscale imaging reveals laterally expanding antimicrobial pores in lipid bilayers. Proc. Natl. Acad. Sci. USA, 220 (22). pp. 8918-8923.

Ryan, L E; Lamarre, B; Ravi, J; Ryadnov, M G (2012) Antimicrobial regulation by host defence peptides. J. Pept. Sci., 18. S58.

Bella, A; Ray, S; Shaw, M; Ryadnov, M G (2012) Arbitrary self-assembly of peptide extracellular microscopic matrices. Angew. Chem. Int. Ed., 51 (2). pp. 428-431.

Cerasoli, E; Ravi, J; Gregor, C*; Hussain, R*; Siligardi, G*; Martyna, G*; Crain, J; Ryadnov, M G (2012) Membrane mediated regulation in free peptides of HIV-1 gp41: minimal modulation of the hemifusion phase.. Phys. Chem. Chem. Phys., 14 (3). pp. 1277-1285.

Tangbunsuk, S*; Whittell, G R*; Ryadnov, M G; Vandermeulen, G W M*; Woolfson, D N*; Manners, I* (2012) Metallopolymer-peptide hydrid materials: synthesis and self-assembly of functional, polyferrocenylsilane-tetrapeptide conjugates. Chem. Eur. J., 18 (9). pp. 2524-2535.

Ryadnov, M G; Cherny, D I* (2012) Natively unfolded state for engineering nanoscale fibrillar arrays. Macromol. Biosci., 12 (2). pp. 195-201.

Gregor, C R*; Cerasoli, E; Schouten, J*; Ravi, J; Slootstra, J*; Horgan, A M; Martyna, G J*; Ryadnov, M G; Davis, P*; Crain, J (2011) Antibody recognition of a human chorionic gonadrtropin epitope (hCG beta(66-80)) depends on local structure retained in the free peptide. J. Biol. Chem., 286 (28). pp. 25016-25026.

Gregor, C R*; Cerasoli, E; Tulip, P R*; Ryadnov, M G; Martyna, G J*; Crain, J (2011) Autonomous folding in the membrane proximal HIV peptide gp41(659-671): pH tuneability at micelle interfaces. Phys. Chem. Chem. Phys., 13 (1). pp. 127-135.

Ravi, J; Hills, A E; Cerasoli, E; Rakowska, P D; Ryadnov, M G (2011) FTIR markers of methionine oxidation for early detection of oxidized protein therapeutics. Eur. Biophys. J., 40 (3). pp. 339-345.

Rakowska, P D; Ryadnov, M G (2011) Nano-enabled biomarker discovery and detection. Biomarkers Med., 5 (3). pp. 387-396.

Lamarre, B; Ryadnov, M G (2011) Self-assembling viral mimetics: one long journey with short steps. Macromol. Biosci., 11 (4). pp. 503-513.

Cerasoli, E; Rakowska, P D; Horgan, A M; Ravi, J; Bradley, M*; Vincent, B*; Ryadnov, M G (2010) MiS-MALDI: microgel-selected detection of protein biomarkers by MALDI-ToF mass spectrometry. Mol. Biosyst., 6 (11). pp. 2214-2217.

Ryadnov, M G; Cerasoli, E; Martyna, G J*; Crain, J (2010) Translational biophysics: the physical sciences in molecular medicine. Future Med. Chem., 2 (11). pp. 1633-1639.