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Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN

Webster, B; Ivanov, P; Russell, B; Collins, S; Stora, T; Ramos, J P; Köster, U; Robinson, A P; Read, D (2019) Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN. Scientific Reports, 9 (1). 10884 ISSN 2045-2322

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Abstract

Four terbium radioisotopes (149, 152, 155, 161Tb) constitute a potential theranostic quartet for cancer treatment but require any derived radiopharmaceutical to be essentially free of impurities. Terbium-155 prepared by proton irradiation and on-line mass separation at the CERN-ISOLDE and CERN-MEDICIS facilities contains radioactive 139Ce16O and also zinc or gold, depending on the catcher foil used. A method using ion-exchange and extraction chromatography resins in two column separation steps has been developed to isolate 155Tb with a chemical yield of ¿95% and radionuclidic purity ¿99.9%. Conversion of terbium into a form suitable for chelation to targeting molecules in diagnostic nuclear medicine is presented. The resulting 155Tb preparations are suitable for the determination of absolute activity, SPECT phantom imaging studies and pre-clinical trials.

Item Type: Article
Subjects: Ionising Radiation > Radioactivity
Divisions: Environment
Identification number/DOI: 10.1038/s41598-019-47463-3
Last Modified: 14 Oct 2019 14:46
URI: http://eprintspublications.npl.co.uk/id/eprint/8517

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