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Super-resolution microscopy in diagnosis of platelet granule disorders.

Knight, A E; Gomez, K*; Cutler, D F* (2017) Super-resolution microscopy in diagnosis of platelet granule disorders. Exp. Rev. Hematol., 10 (5). pp. 375-381.

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Abstract

Platelet granule deficiencies cause a number of disorders of blood clotting. The exact diagnosis or phenotyping of patients requires imaging of the platelet structure; however this has traditionally required the use of electron microscopy (EM) because the granules are too small to be resolved by conventional light microscopy. EM facilities are expensive and not widely available in hospitals, so an alternative approach would be highly beneficial. So-called 'super-resolution' light microscopies offer a potential solution to this problem. In a recent study we demonstrated that one form of super-resolution microscopy - structured illumination microscopy (SIM), is able to reliably discriminate between platelets from patients with a dense granule disorder and those from healthy controls. This approach could be extended to related conditions.

Item Type: Article
Keywords: super-resolution microscope, haematology, structured illumination microscopy, platelets
Subjects: Biotechnology
Biotechnology > Bio-Diagnostics
Divisions: Chemical, Medical & Environmental Science
Identification number/DOI: 10.1080/17474086.2017.1315302
Last Modified: 09 Feb 2018 14:20
URI: http://eprintspublications.npl.co.uk/id/eprint/7573

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