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Abstract

As part of a programme to develop a metrological framework for single molecule measurements in biology, we have investigated the applications of single molecule imaging to genomics. Specifically, we have developed a technique for measuring the frequencies of Single Nucleotide Polymorphisms (SNPs) in complex or pooled samples of DNA. We believe that this technique has applications to statistical genotyping (the identification of correlations between SNP frequencies and particular phenotypes) and other areas where it is desirable to track the frequencies of SNPs in complex DNA populations.

Item Type:	Article
Keywords:	Single molecule imaging, total internal reflection fluorescence microscopy, statistical genotyping, single nucleotide polymorphism
Subjects:	Biotechnology Biotechnology > Bio-Diagnostics
Last Modified:	02 Feb 2018 13:15
URI:	https://eprintspublications.npl.co.uk/id/eprint/4209