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Extracellular matrix type 0: from ancient collagen lineage to a versatile product pipline - JellaGel™

Faruqui, N; Williams, D S; Briones, A; Kepiro, I E; Ravi, J; Kwan, T O C; Mearns-Spragg, A; Ryadnov, M (2023) Extracellular matrix type 0: from ancient collagen lineage to a versatile product pipline - JellaGel™. Materials Today Bio, 22. 100786

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Abstract

Extracellular matrix type 0 is reported. The matrix is developed from a jellyfish collagen which predates mammalian forms by over 0.5 billion years. With its ancient lineage and compositional simplicity, the matrix is referred to as the extracellular matrix type 0. Here we validate the matrix as a functional material describing its physicochemical and biological properties. We demonstrate the use of the material to support cell development exemplified by cell co-culture, neuron firing synchronicity, spheroid formation and 3D culture of immortalised, primary and stem cells. The matrix offers a versatile biological material which underpins a pipeline of commercialised products under the collective name of JellaGel™.

Item Type: Article
Subjects: Advanced Materials > Biomaterials
Divisions: Chemical & Biological Sciences
Identification number/DOI: 10.1016/j.mtbio.2023.100786
Last Modified: 20 Sep 2024 13:35
URI: http://eprintspublications.npl.co.uk/id/eprint/10044

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