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Nanoscale mapping of newly-synthesised phospholipid molecules in biological cells using tip-enhanced Raman spectroscopy.

Kumar, N; Drozdz, M M*; Jiang, H B*; Santos, D M*; Vaux, D J* (2017) Nanoscale mapping of newly-synthesised phospholipid molecules in biological cells using tip-enhanced Raman spectroscopy. Chem. Comms., 53 (16). pp. 2451-2454.

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Abstract

Nanoscale chemical mapping of newly-synthesised phospholipid molecules inside a mammlian cell is demonstrated using tip-enhanced Raman spectroscopy (TERS) for the first time. Mouse pre-adipocyte cells pulse-treated with deuterated sodium stearate, are used as a model system to showcase TERS mapping. Newly-synthesised membrane phospholipid distribution is mapped with less than 20 nm spatial resolution by overcoming the diffraction limit of confocal Raman spectroscopy using strong plasmonic enhancement of Raman signals at a TERS tip-apex.

Item Type: Article
Subjects: Nanoscience
Nanoscience > Surface and Nanoanalysis
Divisions: Chemical, Medical & Environmental Science
Identification number/DOI: 10.1039/c6cc10226c
Last Modified: 09 Feb 2018 14:09
URI: http://eprintspublications.npl.co.uk/id/eprint/7495

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