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Experimental characterisation of holographic optical traps for microbubbles.

Fury, C; Harfield, C; Jones, P H*; Stride, E*; Memoli, G (2014) Experimental characterisation of holographic optical traps for microbubbles. Proc. SPIE - Int. Soc. Opt. Eng., 9126. 91263L

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Abstract

Microbubbles, which have found use in the medical field through improving contrast in ultrasound imaging, are now showing high potential as targeted drug delivery vectors. The characterisation of the acoustical properties of these microbubbles is important in order to validate simulations and devise improvements to their medical applications, thereby leading to safer, more effective and cost-effective medical products. In order to perform this characterisation a system has been constructed based upon simultaneous use of optical and acoustical trapping, with the former providing the reference force calibration and a finer manipulation than the latter.
Here we present results of a study of the characteristics of the optical trap on low-refractive index microbubbles. The microbubbles are trapped in three dimensions in a custom-built microfluidic slide using holographically generated Laguerre-Gaussian beam optical tweezers. We track the Brownian motion of the trapped microbubble via back focal plane interferometry using a separate probe laser beam. The optical potential is then characterised as a function of trapping laser power and trapping beam diameter using the trap spring constant, obtained from the decay of the autocorrelation of position fluctuations and its relation to the known hydrodynamics of the microbubble. A ray optics model of optically trapped microbubbles in a Laguerre-Gaussian beam will be also presented.

Item Type: Article
Keywords: microbubbles, optical tweezers, laguerre-gaussian
Subjects: Acoustics
Acoustics > Ultrasound
Identification number/DOI: 10.1117/12.2055889
Last Modified: 02 Feb 2018 13:13
URI: http://eprintspublications.npl.co.uk/id/eprint/6406

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