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The accuracy and precision of the advanced Poisson dead-time correction and its importance for multivariate analysis of high mass resolution ToF-SIMS data.

Tyler, B J (2014) The accuracy and precision of the advanced Poisson dead-time correction and its importance for multivariate analysis of high mass resolution ToF-SIMS data. Surf. Interface Anal., 46 (9). pp. 581-590.

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Abstract

ToF-SIMS data collected in single ion counting mode suffers from dead-time effects that lead to potentially confusing artefacts when common multivariate analysis (MVA) methods are applied to the data. These artefacts can be reduced by applying an advanced Poisson dead-time correction that accounts for the signal intensity in the dead-time window preceding each time channel. Because this correction is non-linear, it changes the noise distribution in the data. In this work, the accuracy of this dead-time correction and the noise characteristics of the corrected data have been analysed for spectra with small numbers of primary ion pulses. A simple but accurate equation for estimating the standard deviation in the advanced dead-time corrected data has been developed. Based on these results, a scaling procedure to enable successful multivariate analysis of advanced dead-time corrected ToF-SIMS data has been developed. The improvements made possible by using the advanced dead-time correction and our recommended scaling are presented for Principal Components Analysis of a ToF-SIMS image of aerosol particles on PTFE. Recommendations are made for using the advanced dead time correction and scaling ToF-SIMS data in order optimize the outcomes of Multivariate Analysis.

Item Type: Article
Keywords: ToF-SIMS, Mass Spectrometry Imaging, Multivariate Analysis, Pre-processing, Error Analysis
Subjects: Nanoscience
Nanoscience > Surface and Nanoanalysis
Identification number/DOI: 10.1002/sia.5543
Last Modified: 02 Feb 2018 13:14
URI: http://eprintspublications.npl.co.uk/id/eprint/6349

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