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On the generalised case of sequential standard addition calibration.

Brown, R J C; Gillam, T P S* (2012) On the generalised case of sequential standard addition calibration. Chemometr. Intell. Lab. Syst., 110 (1). pp. 97-101.

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Abstract

The generalised case of sequential standard addition calibration is described and explored mathematically. The procedure is generalised by removing the previously imposed requirement for the analysis step not to consume any of the sample. Expressions for the gradient, systematic bias and relative precision of extrapolation have been derived and solved. It has been shown that the characteristics of the calculated gradient and systematic bias of extrapolation for the generalised case are identical to those previously published for cases where no sample is consumed during analysis, depending only on the ratio of target analyte content in the standard to that in the sample. The relative precision of extrapolation has been calculated for a number of different scenarios encompassing all the variables involved in defining the generalised case. It has been demonstrated that the best precision is obtained when the mass of sample removed or consumed during analysis and the mass of standard added for calibration are large compared to the total sample mass.

Item Type: Article
Subjects: Analytical Science
Analytical Science > Trace Analysis and Electrochemistry
Identification number/DOI: 10.1016/j.chemolab.2011.10.004
Last Modified: 23 Jul 2018 14:21
URI: http://eprintspublications.npl.co.uk/id/eprint/5307

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